No effect of anti-TNF-α agents on the surgical stress response in patients with inflammatory bowel disease undergoing bowel resections: a prospective multi-center pilot study

El-Hussuna, Alaa; Qvist, Niels; Zangenberg, Marie Strøm; Langkilde, Anne; Siersma, Volkert; Hjort, Sara; Gögenur, Ismail

doi:10.1186/s12893-018-0425-0

Table 3 The effect of anti-TNF-α treatment on surgical stress response

From: No effect of anti-TNF-α agents on the surgical stress response in patients with inflammatory bowel disease undergoing bowel resections: a prospective multi-center pilot study

Biomarkers of stress	Change from baseline to 6 h.		Change from baseline to 24 h.		Change from baseline to 48 h.		Change from 6 to 24 h.
Biomarkers of stress	median (95% CI)	p	median (95% CI)	p	median (95% CI)	p	median (95% CI)	p
TNF-α	−0.25 (− 3.54; 0.24)	0.49	−0.20 (−1.97; 0.23)	0.44	0.00 (− 0.19; 2.42)	0.37	0.00 (0.00; 0.16)	0.04
IL-6	− 360.46 (− 668.19; 37.01)	0.13	− 200.86 (− 498.45; 29.67)	0.11	− 139.98 (− 276.06; 7.68)	0.12	3.87 (− 62.26; 163.41)	0.84
IL-10	− 0.97 (− 2.52; 1.34)	0.40	−1.29 (− 8.00; 0.17)	0.10	−0.03 (− 1.06; 0.64)	0.88	− 0.25 (− 1.08; 1.16)	0.40
IL-8	2.79 (− 12.25; 27.16)	0.56	5.25 (− 8.90; 17.55)	0.44	5.95 (− 6.83; 11.30)	0.48	−1.10 (−9.10; 7.80)	0.76
IL-17A	0.00 (− 0.03; 0.58)	0.08	0.00 (−1.13; 0.08)	0.70	0.00 (0.00; 0.15)	0.02	0.00 (−2.45; 0.10)	0.14
TNF-α/IL-10 ratio	−0.02 (− 0.30; 1.36)	0.96	0.03 (− 0.10; 3.10)	0.39	0.03 (− 0.15; 0.87)	0.33	0.02 (− 0.12; 0.08)	0.66
IL-6/IL-10 ratio	− 100.15 (− 151.21; 30.79)	0.13	−4.87 (− 145.59; 33.27)	0.59	−72.65 (− 123.24; 6.39)	0.13	18.09 (− 36.61; 63.46)	0.23
WBC	−0.09 (− 4.55; 3.66)	0.97	− 0.01 (− 3.95; 6.31)	0.78	0.27 (− 3.80; 5.82)	0.65	0.25 (−2.75; 4.70)	0.23
CRP	0.00 (− 4.14; 4.59)	0.88	−46.90 (− 76.10; 26.30)	0.22	−104.64 (− 179.39; 76.25)	0.39	−8.45 (− 55.20; 27.11)	0.62
Cortisol	23.80 (− 266.92; 110.51)	0.37	32.01 (− 10.86; 118.55)	0.20	−17.41 (− 137.82; 89.21)	0.51	9.04 (− 6.33; 38.60)	0.26
D-Dimer	−11.14 (− 110.31; 92.14)	0.68	28.59 (− 122.81; 80.70)	0.84	50.64 (− 126.71; 129.29)	0.61	5.95 (− 39.99; 69.11)	0.57
Ferritin	−2.20 (−6.58; 3.50)	0.48	− 0.35 (− 5.08; 3.92)	0.75	−1.33 (− 6.56; 2.98)	0.26	0.60 (− 6.31; 5.60)	0.91
Transferrin	−0.02 (− 0.23; 0.21)	0.93	−0.06 (− 0.30; 0.13)	0.4	−0.20 (− 0.40; 0.09)	0.15	0.02 (− 0.14; 0.11)	0.82

Reported in the table are the differences of the medians of the stress markers between anti-TNF-α naive and anti-TNF-α treated patients. Adjustment for confounding was done by propensity score weighting of the medians. 95% confidence intervals (95%CI) and p-values are estimated using a bootstrap approach
P: refers to p value

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