Table 6 Reviewed papers for Hemostatics Dressing

Bulger et al. [55]

Guidelines

Topical hemostatic agent in combination with direct pressure are effective for bleeding control in pre-hospital settings in anatomical areas where tourniquet cannot be applied

1A

Cox et al. [64]

Retrospective cohort study

HemCon appears to be safe, while QuickClot may produce superficial burns. These products should be taken into account to assist in controlling internal hemorrhage, especially during damage control surgery

2C

Jacobs et al. [56]

Guidelines

Wider civilian use of tourniquet should be encouraged for the control of significant extremity hemorrhage when direct manual compression is ineffective or impractical

1A

Kheirabadi et al. [62]

Experimental, animal

The hemostatic agents are more effective and safe than the currently deployed devices in controlling arterial hemorrhage

2A

Leonard et al. [54]

Retrospective, multicenter

QuickClot is an effective and safe adjunct to control hemorrhage in prehospital setting

2A

McManus [57]

Case series

Zeolite, despite potential complication of thermal injuries, has shown to be a valuable hemostatic agent if used under appropriated circumstances

2C

Rhee et al. [58]

Case series

QuickClot has been proven safe and effective to control prehospital non compressible hemorrhage

2A

Shina et al. [59]

Retrospective

Hemostatic dressing seem to be an effective tool for junctional hemorrhage control and should be considered as second-line treatment for extremity hemorrhage control at the point of injury

1C

Te Grotenhuis et al. [63]

Prospective

Chitogauze is an effective and safe adjunct in the prehospital traatment of massive external traumatic hemorrhage

1C

Waibel et al. [61]

Prospective

Chitosan bandage is safe even in shellfish allergic patients

2C

Wedmore et al. [60]

Retrospective

Chitosan-based hemostatic dressing is useful for prehospital combat casualties

2C