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Table 3 Reviewed papers for adhesives

From: A systematic review on the use of topical hemostats in trauma and emergency surgery

 

Year

Design

Comments

GoR-LoE

Annegg U et al. [31].

2007

Ranzomized, single-center

The use of TachoSil® after pulmonary resection resulted in reduction of air leak with significant shortening of time of tube removal and of hospital length of stay

1C

Belda-Sanchis et al. [32]

2010

Cochrane review

Surgical sealants have some beneficial effects in reducing postoperative air leaks, but their systematic use cannot be recommended at the moment

1A

Briceno et al. [24]

2010

Prospective controlled

The fibrin sealant after major liver resection was effective for decreasing drainage volume; postoperative blood transfusion requirements; moderate to severe postoperative complications and mean hospital stay

1C

Chalmers et al. [3]

2010

Prospective randomized

Tranexamic acid-free fibrin sealant is safe, and significantly shortened the time to haemostasis in vascular procedures using PTFE

1B

Chapman et al. [4]

2007

Phase 3, randomized, double-blind

Recombinant thrombin has comparable efficacy, a similar safety profile, and is considerably less immunogenic than bovine thrombin when used for surgical hemostasis

1C

Cheng et al. [29]

2016

Cochrane review

Considering the lack of effect on prevention of POPF, high costs, and the potential harms for endocrine pancreatic function, fibrin sealants should not be recommended routinely for people undergoing pancreatic surgery

1A

Colombo et al. [14]

2014

Systematic review

TachoSil® has a role as a supportive measure to improve hemostasis and promote tissue sealing when standard techniques are insufficient

1B

Cormio et al. [33]

2012

Prospective randomized

TachoSil sealed tubeless PCNL does not reduce pain and analgesic requirements, but it significantly reduces urinary leakage and postoperative hospital stay

2A

De Boer et al. [19]

2012

Systematic review

Fibrin sealants can be effective as an adjunct to achieve hemostasis during liver resections. However, considering lack of evidence on the efficacy of fibrin sealants in reducing postoperative resection surface-related complications, routine use of fibrin sealants in liver surgery cannot be recommended.

1B

Dhillon et al. [1]

2011

Systematic review

Liquid fibrin sealants are effective as adjunctive measure to improve hemostasis

1B

Echave et al. [2]

2014

Systematic review

Floseal® showed improvement over other hemostatics agents in achieving hemostatis and reducing blood loss

1B

Erdogan et al. [16]

2007

Systematic review

There is no clear proof of the biliostatic efficacy of topical hemostatic agents used after liver resection on the resection surface

1B

Esposito et al. [23].

2016

Systematic review

Fibrin sealants provide a higher rate of intraoperative watertight closure of dura suture line and they may be effective in preventing cerebrospinal fluid leaks with an acceptable safety profile

1B

Figueras et al. [17]

2007

Prospective randomized

Application of fibrin sealants in the raw surface after hepatectomy does not seem justified

1C

Filosso et al. [30]

2013

Prospective randomized

TachoSil® was superior to standard stapling and suturing aerostatic techniques in reducing postoperative air leaks in patients undergoing redo thoracic surgery.

1B

Fisher et al. [5]

2011

Randomized, multicenter

Tranexamic acid- and aprotinin-free fibrin sealant is safe and effective for achieving hemostasis in soft tissue during elective retroperitoneal or intra-abdominal surgery.

1B

Fisher et al. [10]

2013

Prospective randomized

Fibrin pad is superior to absorbable hemostat in soft-tissue bleeding control and is safe and effective for rapidly and reliably achieving hemostasis

1B

Genyk et al. [12]

2016

Multicenter randomized open-lable

The FSP (TachoSil®) was safe and superior to ORCG (Surgicel Original) for achieving hemostasis in patients undergoing hepatic resection

1B

Green et al. [22]

2015

Multicenter, prospective randomized

Fibrin sealant is effective as an adjunct to dural sutures to provide watertight closure of the dura mater in neurosurgery

1C

Jankowitz et al. [21]

2009

Retrospective

The use of fibrin glue for dural repair did not significantly decrease the incidence of a persistent cerebrospinal fluid leak

2A

Kobayashi et al. [18]

2016

Multicenter randomized

Fibrin sealant with polyglicolic acid compared with collagen fleece did not reduce biliary leakage and hemorrhage

1C

Koea et al. [11]

2015

Randomized controlled

The FP is safe and superior to SoC for controlling challenging severe soft-tissue bleeding encountered during intra-abdominal and thoracic surgical procedures

1C

Maisano et al. [13]

2009

Randomized controlled

TachoSil® was significantly superior to standard haemostatic fleece material in obtaining effective and fast intra-operative haemostasis in cardiovascular surgical procedures. TachoSil was safe and well tolerated.

1B

Montorsi et al. [27]

2012

Multicenter randomized controlled

TachoSil® had no significant effect on the rate of POPF, although there was a significant reduction of amylase level in drainage fluid on postoperative day 1.

1B

Marangos et al. [26]

2011

Retrospective

The application of the TachoSil® patch did not affect either occurrence of POPF or duration of postoperative hospital stay. Routine use of TachoSil® patch to prevent pancreatic fistulas does not provide clinically significant benefit.

1C

Perussi Biscola et al. [20]

2017

Systematic review

The new heterologous fibrin sealant from snake venom represents a consistent alternative to biological sealants, since they may avoid transmission of infectious diseases

1C

Pommergaard et al. [26]

2013

Systematic review

Liquid fibrin adhesive should be beneficial to prevent leak of ileal anastomoses in gastric and bariatric surgery

1C

Saha et al. [9]

2012

Prospective randomized

Fibrin sealant is safe and its efficacy is superior to manual compression for hemostasis in patients with vascular ePTFE graft

1C

Schwartz et al. [6]

2004

Prospective randomized controlled

Crosseal fibrin sealant significantly reduces the time of hemostasis following liver resection in comparison with the standard topical hemostatic agents

1C

Simo et al. [15]

2012

Systematic review

Application of TachoSil® in hepatobiliary and pancreatic surgery has proven effectiveness in hemostasis and as tissue sealant

1C

Spotniz et al. [7]

2012

Systematic review

Fibrin sealants have multiple new uses that should result in further improvement in patient care

1C

Taylor et al.[8]

2003

Randomized prospective multicenter

Fibrin sealants are more effective than thrombin-soaked gelatin sponge for achieving hemostasis of needle or suture hole bleeding from PTFE femoral artery grafts.

1B

Vakalopoulos et al. [25]

2012

Systematic review

Fibrin sealant seem not be necessary as external coating of colonic anastomoses to prevent leakage

1C