Table 1 Patient demographics and clinical characteristics
Variablea | Value |
|---|---|
Gender, n (%) | 400 (100) |
 Female | 349 (87.2) |
 Male | 51 (12.8) |
Age in years, mean (SD) | 57.2 (13.4) |
Weight in kg, mean (SD) | 79.2 (15.8) |
Thyrotoxicosis before surgery, n (%) | |
 No | 277 (69.2) |
 <10 years | 105 (26.3) |
 ≥10 years | 18 (4.5) |
Graves’ disease, n (%) | |
 No | 379 (94.7) |
 Yes | 21 (5.3) |
Recurrent goiter, n (%) | |
 No | 397 (99.2) |
 Yes | 3 (0.8) |
Retrosternal goiter, n (%) | |
 No | 393 (98.2) |
 Yes | 7 (1.8) |
Bone mass density, T level, n (%) | |
 No | 394 (98.5) |
 Yes | 6 (1.5) |
Preoperative calcium, mmol/L, mean (SD) | 2.36 (0.10) |
MD (IQR) | 2.36 (0.12) |
Preoperative ionized calcium, mmol/L, mean (SD) | 1.06 (0.08) |
MD (IQR) | 1.04 (0.07) |
Preoperative PTH, ng/L (pg/mL), mean (SD) | 57.71 (22.27) |
MD (IQR) | 53.90 (26.63) |
Preoperative 25-hydroxyvitamin D, nmol/L, mean (SD) | 45.27 (22.03) |
MD (IQR) | 41.78 (29.72) |
Preoperative TSH, mlU/L, mean (SD) | 0.94 (1.22) |
MD (IQR) | 0.75 (1.22) |
Preoperative FT3, pmol/L, mean (SD) | 4.87 (2.36) |
MD (IQR) | 4.66 (0.84) |
Preoperative FT4, pmol/L, mean (SD) | 13.31 (2.69) |
MD (IQR) | 13.43 (2.71) |
Thyroidectomy without lymphadenectomy, n (%) | 400 (100) |
 No | 66 (16.5) |
 Yes | 334 (83.5) |
Thyroidectomy with one sided central lymphadenectomy, n (%) | |
 No | 344 (86.0) |
 Yes | 56 (14.0) |
Thyroidectomy with central lymphadenectomy on both sides, n (%) | |
 No | 390 (97.5) |
 Yes | 10 (2.5) |
Number of observed parathyroid glands, n (%) | |
 0 | 2 (0.5) |
 1 | 8 (2.0) |
 2 | 97 (24.2) |
 3 | 208 (52.0) |
 4 | 85 (21.3) |
Upper branch of left inferior thyroid artery, n (%) | |
 Non-ligation | 363 (90.7) |
 Ligation | 37 (9.3) |
Lower branch of left inferior thyroid artery, n (%) | |
 Non-ligation | 366 (91.5) |
 Ligation | 34 (8.5) |
Trunk of left inferior thyroid artery, n (%) | |
 Non-ligation | 90 (22.5) |
 Ligation | 310 (77.5) |
Upper branch of right inferior thyroid artery, n (%) | |
 Non-ligation | 358 (89.5) |
 Ligation | 42 (10.5) |
Lower branch of right inferior thyroid artery, n (%) | |
 Non-ligation | 366 (91.5) |
 Ligation | 34 (8.5) |
Trunk of right inferior thyroid artery, n (%) | |
 Non-ligation | 91 (22.8) |
 Ligation | 309 (77.2) |
Number of darkened parathyroid glands at the end of surgery, n (%) | |
 0 | 305 (76.2) |
 1 | 80 (20.0) |
 2 | 9 (2.3) |
 3 | 6 (1.5) |
Parathyroid gland hematoma, n (%) | |
 No | 379 (94.7) |
 Yes | 21 (5.3) |
Number of autotransplanted parathyroid glands, n (%) | |
 0 | 332 (83.0) |
 1 | 54 (13.4) |
 2 | 11 (2.8) |
 3 | 3 (0.8) |
Adenomatous nodules, n (%) | |
 No | 334 (83.5) |
 Yes | 66 (16.5) |
Colloidal nodules, n (%) | |
 No | 130 (32.5) |
 Yes | 270 (67.5) |
Papillary carcinoma, n (%) | |
 No | 320 (80.0) |
 Yes | 80 (20.0) |
Follicular carcinoma, n (%) | |
 No | 399 (99.7) |
 Yes | 1 (0.3) |
Medullary carcinoma, n (%) | |
 No | 397 (99.3) |
 Yes | 3 (0.8) |
Anaplastic carcinoma, n (%) | |
 No | 400 (100) |
Autoimmune thyroiditis, n (%) | |
 No | 363 (90.7) |
 Yes | 37 (9.3) |
Calcium day one, mmol/L, mean (SD) | 2.12 (0.14) |
MD (IQR) | 2.11 (0.20) |
Ionized calcium day one, mmol/L, mean (SD) | 0.99 (0.08) |
MD (IQR) | 0.99 (0.10) |
PTH day one, ng/L (pg/mL), mean (SD) | 29.98 (19.46) |
MD (IQR) | 29.06 (27.61) |
Calcium day two, mmol/L, mean (SD) | 2.05 (0.16) |
MD (IQR) | 2.06 (0.22) |
Ionized calcium day two, mmol/L, mean (SD) | 0.98 (0.09) |
MD (IQR) | 0.98 (0.11) |
Revision for bleeding, n (%) | |
 No | 396 (99.0) |
 Yes | 4 (1.0) |
Wound infection, n (%) | |
 No | 400 (100) |
Wound hematoma, n (%) | |
 No | 389 (97.2) |
 Yes | 11 (2.8) |
Bleeding during surgery, n (%) | |
 No | 399 (99.7) |
 Yes | 1 (0.3) |
Clinical voice hoarseness, n (%) | |
 No | 384 (96.0) |
 Yes | 16 (4.0) |
Recurrent laryngeal nerve paralysis on one side, ORL, n (%) | |
 No | 392 (98.0) |
 Yes | 8 (2.0) |
Recurrent laryngeal nerve paralysis on both sides, ORL, n (%) | |
 No | 400 (100) |
Clinical manifestation of hypocalcemia, n (%) | |
 None | 340 (85.0) |
 Day one | 14 (3.5) |
 Day two | 46 (11.5) |
Hypocalcemia without clinical manifestation, n (%) | |
 No | 203 (50.7) |
 Yes | 197 (49.3) |
Hypocalcemia - Chvostekʼs symptoms, n (%) | |
 No | 386 (96.5) |
 Yes | 14 (3.5) |
Hypocalcemia - Trousseau’s symptoms, n (%) | |
 No | 392 (98.0) |
 Yes | 8 (2.0) |
Hypocalcemia - Numbness of fingers, n (%) | |
 No | 342 (85.5) |
 Yes | 58 (14.5) |
Hypocalcemia, n (%) | |
 No | 143 (35.8) |
 Yes | 257 (64.2) |
Treatment commenced in hospital with calcium and vitamin D preparations after surgery, n (%) | |
 None | 161 (40.3) |
 Day 1 | 15 (3.8) |
 Day 2 | 33 (8.3) |
 Day 3 | 5 (1.3) |
 On discharge | 186 (46.5) |