Table 1 Overview of previous reported case of colonic and hepatic actinomycosis

 4

1

Left colon

41

Female

Abdominal pain, nausea, constipation

+

–

+

Tumor of colon or retroperitoneum

Histologic diagnosis of surgical specimen

Complete excision of mass with colectomy + actinomycosis medication

 30

1

Transverse colon

37

Female

Abdominal pain with a sensation of fullness

–

–

+

Colon cancer

Histologic diagnosis of surgical specimen

Colectomy + actinomycosis medication

 2

4

Sigmoid, rectum

48.8 (38–55)

Male: 2 case

Female: 2 case

Abdominal pain, constipation, weight loss, indigestion

+(1 female)

All case: +

n.av

colorectal cancer

Histologic diagnosis of surgical specimen: 3 case

Biopsy: 1 case

3 case: colectomy + actinomycosis medication

1 case: actinomycosis medication

 19

1

Rectosigmoid, right colon, uterus, adnexa,

49

Female

Abdominal pain, constipation, vomiting

+

n.av

n.av

Colon cancer

Histologic diagnosis of surgical specimen

Colectomy + ovary excision + actinomycosis medication

 28

1

Rectosigmoid, right ureter

63

Male

Abdominal pain, constipation, malaise, weight loss

n.ap

+

–

colon cancer

Biopsy

Diverting sigmoidostomy + ureteral stent + actinomycosis medication

 29

1

Sigmoid, uterus, adnexa, right ureter

63

Female

Abdominal pain, fever

+

+

–

Pelvic actinomycosis or malignancy

Histologic diagnosis of surgical specimen

Total hysterectomy, bilateral salphigo-oophorectomy, adhesiolysis around urter + actinomycosis medication

 8

1

Sigmoid

39

Male

Abdominal pain

n.ap

+

n.av

Colon perforation due to obstructing colon cancer

Histologic diagnosis of surgical specimen

Colectomy, ileostomy + actinomycosis medication

 31

1

Sigmoid, both adnexa

38

Female

Abdominal pain, constipation, fever

+

+

n.av

Crohn;s disease or sigmoid tumor

Histologic diagnosis of surgical specimen

Colectomy + bilateral salphingo-oophorectomy + actinomycosis medication

 18

1

Rectosigmoid, uterus, adnexa, left ureter

42

Female

Pelvic discomfort, constipation

+

–

+

Advanced Ovarian cancer

Histologic diagnosis of surgical specimen

Neoadjuvant chemotherapy +total hysterectomy, bilateral salphingo-oophorectomy, rectosigmoid resection + ureteral stent + actinomycosis medication

 20

11

Right lobe: 1 case

Left lobe: 2 case

Central area: 1 case

No data: 7 case

55 (20–86)

Male: 7 case

Female: 4 case

Fever: 9/11 (81.9%)

Abdominal pain: 6/11 (54.5%)

Palpable mass: 4/11 (36.4%)

Back pain: 2/11 (18.2%)

Nausea, vomiting: 2/11 (18.2%)

Anorexia: 1/11 (9%)

Diarrhea: 1/11 (9%)

No clinical sign: 1/11 (9%)

n.av

+: 7/9 (77.8%)

+: 2/9 (22.2%)

Liver tumor: 6/11 (54.5%)

Liver abscess: 5/11 (45.5%)

Histologic diagnosis of surgical specimen: 6/11 (54.5%)

Biopsy: 1/11 (9%)

Sulfur granule in pus: 2/11 (18.2%)

Actinomyces culture: 2/11 (18.2%)

Liver resection + actinomycosis medication: 5/11 (45.5%)

Surgical or percutaneous drainage + actinomycosis medication: 5/11 (45.%)

Liver resection only: 1/11 (9%)

 11

1

Liver (both lobe)

70

Male

Fever, abdominal pain, anorexia, weight loss

n.ap

+

+

Hepatic metastasis

Biopsy

Actinomycosis medication

 10

1

Right lobe, single lesion

65

Male

Incidental finding of regular surveillance after pancreatic adenocarcinoma

n.ap

–

n.av

Metastatic liver tumor

Histologic diagnosis of surgical specimen

Liver resection + actinomycosis medication

 9

1

Liver (right lobe), ovary

41

Female

Abdominal pain

+

+

+

Ovarian cancer with hepatic metastasis

Histologic diagnosis of surgical specimen

Rt. Salpingo-oophorectomy + IUD removal + acitomycosis medication

 3

1

Liver(multiple nodules on surface), spleen

37

Male

Fever, abdominal pain

n.ap

+

–

Spleen abscess

Histologic diagnosis of surgical specimen

Splenectomy + liver biopsy + actinomycosis medication

 13

1

Left lobe

55

Male

Abdominal pain, weight loss

n.ap

–

–

Liver tumor

Histologic diagnosis of surgical specimen

Liver resection + actinomycosis medication

32 (data of analysis in literature)

Right lobe: 19/29 (65.5%)

Both lobe: 8/29 (27.6%)

Left lobe: 2/29 (6.9%)

45.5 (5–86)

Male: 19 (59%)

Female: 13 (41%)

Fever: 25/27 (92.6%)

Weight loss: 15/25 (60%)

2 (6.3%)

+: 27/29 (93.1%)

+: 17/24 (70.8%)

Liver tumor: 20/28 (71.4%)

Hepatophyta: 8/28 (28.6%)

Liver hydatidosis: 2/28 (7.1%)

Inflammatory pseudotumor: 1/28 (3.65%)

Tuberculosis: 1/2 (3.65%)

Gram staining: 22/27 (81.5%)

Histologic diagnosis of sulfur granule: 22/31 (71%)

Actinomyces culture: 10/20 (50%)

Only actinomycosis medication: 14/32 (43.8%)

Surgical or percutaneous drainage + actinomycosis medication: 12/32 (37.5%)

Liver resection + actinomycosis medication: 6/32 (18.7%)