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Table 3 Summary of included publications

From: Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review

Author Usami
et al.
et al.
et al.
et al.
et al.
Year 2010 2012 2013 2013 2012
Country Japan China Japan Japan Japan
Study type RCT RCT RCT Cohort RCT
Treatment Synbiotics vs. no Treatment Probiotics vs. Placebo Synbiotics vs. no Treatment n. s. Synbiotics vs. Probiotics
Number of patients included 61 (29 + 32) 60 (30 + 30) 48 (25 + 23) 81 64 (30 + 34)
Area of surgery Liver Colon Pankreas/Bile-System Colon Oesophagus
Method of quantification Culture Culture PCR PCR PCR
C-reactive Protein No difference No difference n. s.
White blood cell count n. s. No difference n. s.
SIRS n. s. n. s.
Organic acids in stool n. s. a
Stool pH n. s. No difference
Rate of infections 7,4%
Number of pathogenetic bacteria a
Number of Lactobacilli and Bifidobacteria a
  1. If not specified elsewhere, the arrows show the postoperative comparison of the synbiotic/probiotic-treated patients compared to control groups
  2. n. s. not specified, RCT Randomized controlled trial, SIRS Systemic inflammatory response syndrome
  3. aCompared to preoperative measures