Table 1 Clinical and cost inputs
Parameter | Value | Range | Distribution for probabilistic sensitivity analysis | Source |
|---|---|---|---|---|
Patient baseline characteristic | ||||
 Age, years | 40.4 | 25–65 | Normal (SE = 4.04) | Stroh 2009 [23] |
 Gender, males (%) | 26.3 | - | Beta (α = 1315; λ = 3685) | Stroh 2013 [26] |
 Systolic blood pressure, mmHg | 140.1 | 125–200 | Gamma (α = 55.53; λ = 2.52) | Sjöström [20] |
 Body mass index, kg/m2 | 48.8 | 30–60 | Normal (SE = 6.5) | Stroh 2013 [26] |
 Diabetes mellitus, (%) | 20.6 | - | Beta (α = 1030; λ = 3970) | Stroh 2013 [26] |
 Smoking, (%) | 21.9 | - | Beta (α = 1095; λ = 3905) | OECD factbook [52] |
Cost inputs | ||||
 Cost of AGB | 5621 | 4497–6745 | - | G-DRG tariff K04B [40] |
 Cost of GBP and SG | 8104 | 6483–9725 | - | G-DRG tariff K04A [40] |
 Annual cost of T2D | 3867 | 1934–7734 | Gamma (α = 100; λ = 38.67) | Drabik 2012 [41] |
 Annual cost of acute stroke | 4054 | 2027–8108 | Gamma (α = 100; λ = 40.54) | Dodel 2004 (ratio of IS and HS is informed by Wolf 1992) [42] [43] |
 Annual cost of post-stroke 1 year | 5493 | 2747–10,986 | Gamma (α = 100; λ = 54.93) | Rossnagel 2005 [44] |
 Annual cost of post-stroke 2 year | 6268 | 3134–12,536 | Gamma (α = 100; λ = 62.68) | Kolominsky-Rabas 2006 [45] |
 Cost of transient ischemic attack | 3327 | 2662–4159 | Gamma (α = 100; λ = 33.27) | Dodel 2004 [42] |
 Cost of acute myocardial infarction | 7644 | 3822–15,288 | Gamma (α = 100; λ = 76.44) | Reinhold 2011 [46] |
 Annual cost of post-MI state | 7056 | 3528–14,112 | Gamma (α = 100; λ = 70.56) | Reinhold 2011 [46] |
 Annual cost of heart failure | 5393 | 2697–10,786 | Gamma (α = 0.34; λ = 15,982.32) | Peters-Klimm 2012 [47] |
 Annual cost of peripheral artery disease | 2897 | 1449–5794 | Gamma (α = 100; λ = 28.97) | Bruggenjurgen 2012 [48] |
 Annual cost of angina pectoris | 3899 | 1950–7798 | Gamma (α = 100; λ = 38.99) | Krankenhausdiagnosestatistik, 1997 [49] Statistisches Bundesamt Deutschland, 2005 [50] |