Fig. 3

Study results. (a) Oral and single-dose i.v. Atorvastatin treatment reduced serum ALT at 7 d after bile duct ligation. (b) Atorvastatin 5 mg/kg administered 24 h before I/R was identified as the most effective dose at reducing serum ALT 6 h after I/R. (c) Despite its protective capacity at 6 h after I/R, atorvastatin 5 mg/kg administered 24 h before I/R did not reduce serum ALT or necrosis at 24 h after I/R. (d) No effect in serum ALT or necrosis was observed when atorvastatin 5 mg/kg was administered 30 min before I/R. (e) Representative histological sections (H&E) of I/R-subjected cholestatic rat livers treated by vehicle or ATV at 24 h or 30 min before the induction of ischemia. The white arrows point to patches of confluent necrosis. Original magnification 2.5 ×