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Table 4 Univariate analysis of predictors for adverse surgical outcome

From: Postoperative fluid overload is a risk factor for adverse surgical outcome in patients undergoing esophagectomy for esophageal cancer: a retrospective study in 335 patients

Parameter

Number

Adverse surgical outcomea

Pb

Total

335

174 (52%)

 

Sex (n, %)

  

0.389

 Male

290

152 (53%)

 

 Female

45

22 (49%)

 

ASA score (n, %)

  

0.002

 1 – 2

193

87 (45%)

 

 3 – 4

142

87 (61%)

 

BMI

  

0.252

 <25 kg/m2

179

96 (53%)

 

 ≥25 kg/m2

154

76 (49%)

 

Recent Smoking (n, %)

  

0.036

 Yes

170

97 (57%)

 

 None

165

77 (47%)

 

Multimodal therapy (n, %)

  

0.081

 None

73

43 (59%)

 

 Neoadjuvant radiochemotherapy

189

101 (53%)

 

 Perioperative chemotherapy

73

30 (41%)

 

Surgical approach (n, %)

  

0.342

 Thoracoabdominal

309

159 (52%)

 

 Transhiatal

26

15 (58%)

 

Reconstruction (n, %)

  

0.036

 Gastric tube

321

163 (51%)

 

 Colon interposition

14

11 (79%)

 

Anastomosis (n, %)

  

0.017

 Intrathoracic

185

88 (59%)

 

 Cervical

150

86 (47%)

 

Tumor histological type (n, %)

  

0.383

 Squamous cell carcinoma

137

73 (53%)

 

 Adenocarcinoma

198

101 (51%)

 

UICC-Stage (n, %)

  

0.149

 1 – 2

251

135 (54%)

 

 3 – 4

84

39 (46%)

 

Treatment period

  

0.015

 1996 – 2005

159

93 (53%)

 

 2006 – 2014

176

81 (46%)

 

Perioperative blood transfusion

  

0.038

 Yes

203

112 (55%)

 

 No

126

56 (44%)

 

Intraoperative fluid rate

  

0.479

 <13 ml/kg/h

166

85 (51%)

 

 ≥13 ml/kg/h

167

87 (52%)

 

Fluid balance POD 0

  

0.001

 <6000 ml

166

71 (43%)

 

 ≥6000 ml

166

100 (61%)

 

Fluid balance POD 4

  

0.001

 <5500 ml

164

69 (42%)

 

 ≥5500 ml

165

99 (60%)

 
  1. aAt least one Complication grade 3 or higher graded according to Clavien/Dindo, bFisher's exact test
  2. We performed a risk factors analysis for the occurrence of adverse surgical outcome (defined as at least one complication graded 3 or higher). Displayed are the analysed risk factors and their impact on the outcome