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Table 2 Operative and perioperative details at time of liver-directed therapy of our study population (n = 35 patients) according to state of Tyrosinkinase Inhibitor (TKI) Therapy

From: The value of hepatic resection in metastasic renal cancer in the Era of Tyrosinkinase Inhibitor Therapy

Variables Total (n = 35) TKI+ (n = 16) TKI- (n = 19) p-value
Extent of resection
 Minor resection 17 (51.5 %) 11 (33.3 %) 6 (18.2 %) 0.008d
 Major 16 (48.5 %) 3 (9.1 %) 13 (39.4 %)
Type of liver resection
 Segmental resection 9 (27.3 %) 6 (18.2 %) 3 (9.1 %) 0.13d
 Anatomical right/left resection 11 (33.3 %) 9 (27.2 %) 2 (6.1 %) 0.003d
 Extended resection right/left 5 (15.2 %) 4 (12.1 %) 1 (3.1 %) 0.06d
 Atypical resection 8 (24.2 %) 4 (12.1 %) 4 (12.1 %) 0.61d
Resection Margin
 Complete Resection (R0) 30 (85.7 %) 14 (40 %) 16 (45.7 %) 0.78d
 Microscopically positive margin (R1) 5 (14.3 %) 2 (5.7 %) 3 (8.6 %)
Transfusion intraoperative
 Substitution 15 (8 %) 9 (4.8 %) 3 (1.6 %) 0.7d
  - Transfusion erythrocyte concentrations 0.27 (0–6) 0.23 (0–6) 0.36 (0–4) 0.7d
  - Transfusion Fresh frozen plasma 0.17 (0–8) 0.2 (0–8) 0.03 (0–1) 0.7d
 Pringle manoeuvre 19 (54.3 %) 6 (17.1 %) 13 (37.1 %) 0.067c
 Median Hospital stay (days) 18.7 (11–28) 16.6 (11–18) 20.5 (16–24) 0.360a
 Median Intensive care unit stay (days) 1.9 (1–6) 2.0 (1–6) 1.8 (1–5) 0.716a
 Median Operating time (min) 238 (161.5–276) 224.5 (164.5–272.5) 242 (155–281) 0.477a
Complications
 Grade I 0 (0 %) 0 (0 %) 0 (0 %) -
 Grade II 3 (8.6 %) 2 (5.7 %) 1 (2.9 %) 0.434d
 Grade IIIa 5 (14.3 %) 4 (11.4 %) 1 (2.9 %) 0.096d
 Grade IIIb 1 (2.9 %) 0 (0 %) 1 (2.9 %) 0.352d
 Grade Iva 1 (2.9 %) 1 (2.9 %) 0 (0 %) 0.269d
 Grade IVb 0 (0 %) 0 (0 %) 0 (0 %) -
 Grade V 0 (0.5 %) 0 (0 %) 0 (0 %) -
  1. Used Statistical tests:
  2. aStudent’s t-test
  3. bWilcoxon rank sum test
  4. cchi-squared test
  5. dFisher’s exact test