Table 1 Characteristic of patients with CR-HCC, B-HCC, and C-HCC
From: Long-term prognosis after resection of cryptogenic hepatocellular carcinoma
|  | CR-HCC (n = 62) | B-HCC (n = 167) | C-HCC (n = 401) | p-value CRvsB/ CRvsC/BvsC |
|---|---|---|---|---|
Preoperative and operative factors | ||||
 Age (years) | 68 (36–81) | 54 (28–78) | 64 (40–87) | <0.001/ 0.053/ <0.001 |
 Gender (Male/Female) | 46/16 | 144/23 | 287/114 | 0.028/ 0.397/ <0.001 |
 BMI | 22.7 (14.0–29.3) | 22.9 (17.4–33.8) | 22.8 (15.5–40.4) | 0.879/ 0.951/ 0.692 |
 Diabetes Mellitus | 25 (40.3 %) | 18 (10.7 %) | 55 (13.7 %) | <0.001/ <0.001/0.341 |
 Hypertension | 24 (38.7 %) | 16 (9.6 %) | 58 (14.5 %) | <0.001/ <0.001/0.115 |
 Plt | 16.2 (4.6–32.9) | 14.1 (1.5–30.1) | 11.9 (3.1–32.9) | 0.055/ 0.005/ 0.119 |
 AFP | 7.2 (1.6–23,530) | 11 (0.8–66,810) | 21.9 (1–137,000) | 0.201/ 0.532/ 0.074 |
 DCP | 38 (0.07–23,676) | 21 (0.07–10,200) | 17 (0.07–18,703) | 0.033/ <0.001/ 0.033 |
 Anatomical resection | 22 (35.5 %) | 36 (21.6 %) | 74 (18.5 %) | 0.017/ 0.001/ 0.205 |
 ICG | 15.5 (3–68) | 12 (3–53) | 21 (3–96) | 0.023/ 0.002/ <0.001 |
 Child (A/B/C) | 60/ 2/ 0 | 152 /15/ 0 | 357/ 44/ 0 | 0.431/ 0.218/ 0.102 |
 MELD score (Median) | 7 (6–12) | 7 (6–14) | 7 (6–14) | 0.322/ 0.456/ 0.120 |
Pathological factors | ||||
 Tumor size (mm):greatest dimension | 28 (9–114) | 22 (6–120) | 21 (2–100) | 0.002/ <0.001/ 0.561 |
 Poorly differentiated tumor | 15 (24.2 %) | 36 (21.6 %) | 68 (17.0 %) | 0.529/ 0.182/ 0.108 |
 Multiple tumor | 11 (17.7 %) | 18 (10.8 %) | 60 (15.0 %) | 0.129/ 0.346/ 0.130 |
 Cancer spread | 20 (32.3 %) | 39 (23.4 %) | 86 (21.4 %) | 0.153/ 0.066/ 0.346 |
 LC | 16 (25.8 %) | 101 (60.5 %) | 239 (59.6 %) | <0.001/ <0.001/ 0.405 |
Overall survival rate | ||||
 1 year | 96.7 % | 95.8 % | 97.5 % | 0.478/ 0.417/ 0.001 |
 3 years | 87.9 % | 86.9 % | 87.6 % | |
 5 years | 75.0 % | 81.6 % | 74.7 % | |
 10 years | 56.1 % | 58.4 % | 39.3 % | |
Disease-free survival rate | 28/62 (45.2Â %) | 99/167 (59.3Â %) | 274/401 (68.3Â %) | 0.575/ 0.026/ 0.004 |
 1 year | 81.4 % | 79.3 % | 81.9 % | |
 3 years | 64.4 % | 61.6 % | 48.8 % | |
 5 years | 50.4 % | 48.6 % | 34.0 % | |
 10 years | 34.9 % | 27.2 % | 18.5 % | |
Site and patterns of initial recurrence | ||||
 Marginal and same subsegment | 3 (10.7 %) | 14 (14.3 %) | 52 (19.0 %) |  |
 Other subsegment | 20 (71.4 %) | 80 (80.8 %) | 213 (77.7 %) |  |
 Extrahepatic recurrence. | 5 (17.9 %) | 5 (5.1 %) | 9 (3.3 %) |  |