Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children

BMC Surgery

Table 5 Best cut-off values, specifity, sensitivity, and areas under the curve (AUC) with 95 % confidence intervals estimated for CRP, IL-6 and WBC. Significantly best parameters are shown bold with italic p values in comparison to WBC.

		Criterion	Sensitivity	95% CI	Specificity	95% CI	AUC	sign.	95% CI
1 vs. 4	WBC	>14.3	80	51.9 – 95.4	62.5	24.7 – 91.0	0.667	n.s.	0.442 – 0.847
	IL-6	>12.2	93.3	68.0 – 98.9	100	62.9 – 100.0	0.992	<.005	0.836 – 1.000
	CRP	>11	86.7	59.5 – 98.0	100	62.9 – 100.0	0.937	<.01	0.752 – 0.992
1 vs. 3+4	WBC	>14.3	75.8	57.7 – 88.9	62.5	24.7 – 91.0	0.644	n.s.	0.479 – 0.787
	IL-6	>12.2	75.8	57.7 – 88.9	100	62.9 – 100.0	0.903	<.01	0.770 – 0.973
	CRP	>11	69.7	51.3 – 84.4	100	62.9 – 100.0	0.843	<.05	0.695 – 0.937
2 vs. 4	WBC	>18	73.3	44.9 – 92.0	58.8	33.0 – 81.5	0.569	n.s.	0.382 – 0.741
	IL-6	>21.7	86.7	59.5 – 98.0	82.4	56.6 – 96.0	0.833	<.02	0.660 – 0.940
	CRP	>42	80	51.9 – 95.4	94.1	71.2 – 99.0	0.894	<.005	0.734 – 0.974
2 vs. 3+4	WBC	>12.6	87.9	71.8 – 96.5	41.2	18.5 – 67.0	0.542	n.s.	0.395 – 0.684
	IL-6	>21.7	63.6	45.1 – 80.1	82.4	56.6 – 96.0	0.736	<.05	0.592 – 0.851
	CRP	>26	66.7	48.1 – 83.1	82.4	56.6 – 96.0	0.731	n.s.	0.587 – 0.846
3 vs. 4	WBC	>18.2	73.3	44.9 – 92.0	61.1	35.3 – 82.9	0.613	n.s.	0.428 – 0.777
	IL-6	>23.1	86.7	59.5 – 98.0	66.7	41.0 – 86.6	0.719	n.s.	0.535 – 0.860
	CRP	>46	80	51.9 – 95.4	88.9	65.2 – 98.3	0.835	<.05	0.665 – 0.940
1+2 vs. 3+4	WBC	>12.6	87.9	71.8 – 96.5	44	24.4 – 65.1	0.575	n.s.	0.438 – 0.703
	IL-6	>12.2	75.8	57.7 – 88.9	76	54.9 – 90.6	0.79	n.s.	0.663 – 0.886
	CRP	>26	60.6	42.1 – 77.1	88	68.8 – 97.3	0.767	n.s.	0.637 – 0.868

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