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Table 5 Best cut-off values, specifity, sensitivity, and areas under the curve (AUC) with 95 % confidence intervals estimated for CRP, IL-6 and WBC. Significantly best parameters are shown bold with italic p values in comparison to WBC.

From: Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children

   Criterion Sensitivity 95% CI Specificity 95% CI AUC sign. 95% CI
1 vs. 4 WBC >14.3 80 51.9 – 95.4 62.5 24.7 – 91.0 0.667 n.s. 0.442 – 0.847
  IL-6 >12.2 93.3 68.0 – 98.9 100 62.9 – 100.0 0.992 <.005 0.836 – 1.000
  CRP >11 86.7 59.5 – 98.0 100 62.9 – 100.0 0.937 <.01 0.752 – 0.992
1 vs. 3+4 WBC >14.3 75.8 57.7 – 88.9 62.5 24.7 – 91.0 0.644 n.s. 0.479 – 0.787
  IL-6 >12.2 75.8 57.7 – 88.9 100 62.9 – 100.0 0.903 <.01 0.770 – 0.973
  CRP >11 69.7 51.3 – 84.4 100 62.9 – 100.0 0.843 <.05 0.695 – 0.937
2 vs. 4 WBC >18 73.3 44.9 – 92.0 58.8 33.0 – 81.5 0.569 n.s. 0.382 – 0.741
  IL-6 >21.7 86.7 59.5 – 98.0 82.4 56.6 – 96.0 0.833 <.02 0.660 – 0.940
  CRP >42 80 51.9 – 95.4 94.1 71.2 – 99.0 0.894 <.005 0.734 – 0.974
2 vs. 3+4 WBC >12.6 87.9 71.8 – 96.5 41.2 18.5 – 67.0 0.542 n.s. 0.395 – 0.684
  IL-6 >21.7 63.6 45.1 – 80.1 82.4 56.6 – 96.0 0.736 <.05 0.592 – 0.851
  CRP >26 66.7 48.1 – 83.1 82.4 56.6 – 96.0 0.731 n.s. 0.587 – 0.846
3 vs. 4 WBC >18.2 73.3 44.9 – 92.0 61.1 35.3 – 82.9 0.613 n.s. 0.428 – 0.777
  IL-6 >23.1 86.7 59.5 – 98.0 66.7 41.0 – 86.6 0.719 n.s. 0.535 – 0.860
  CRP >46 80 51.9 – 95.4 88.9 65.2 – 98.3 0.835 <.05 0.665 – 0.940
1+2 vs. 3+4 WBC >12.6 87.9 71.8 – 96.5 44 24.4 – 65.1 0.575 n.s. 0.438 – 0.703
  IL-6 >12.2 75.8 57.7 – 88.9 76 54.9 – 90.6 0.79 n.s. 0.663 – 0.886
  CRP >26 60.6 42.1 – 77.1 88 68.8 – 97.3 0.767 n.s. 0.637 – 0.868