Table 5 Risk factors associated with recurrence-free survival

Age (years)

< 60 vs. ≥ 60

1.2 (0.6 − 2.4)

0.5

NA

Gender

Male vs. female

1.2 (0.5 − 2.6)

0.7

NA

Tumor location

Upper, mid vs. low

1.4 (0.7 − 2.7)

0.4

NA

Operation type

LAR vs. APE or Hartmann

0.6 (0.3 − 1.6)

0.4

NA

Duration (preoperative CRT to surgery) (week)

<6 vs. ≥6

0.8 (0.4 − 1.6)

0.5

NA

Tumor diameter (cm)

<3 vs. ≥3

1.5 (0.8 − 3.1)

0.2

NA

ypTNM

pCR,I vs. II,III,IV

3.4 (1.7 − 6.8)

0.001

3.1 (1.5 − 6.2)

0.002

CEA (ng/mL)

< 5 vs. ≥ 5

1.7 (0.8 − 3.7)

0.2

1.3 (0.6 − 2.9)

0.5

NLR

< 3 vs. ≥ 3

3.6 (1.5 − 8.9)

0.01

2.8 (1.1 − 6.8)

0.03