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Table 3 Possible risk factors for anastomotic insufficiency following intrahepatic cholangiojejunostomy

From: Post-operative depletion of platelet count is associated with anastomotic insufficiency following intrahepatic cholangiojejunostomy: a case–control study from the results of 220 cases of intrahepatic cholangiojejunostomy

    Univariate analysis Multivariate analysis
Subject characteristics   Anastomotic insufficiency (n =13) P Odds ratio 95% CI P
Age (years) 68 > (n =102) 7 1    
Sex Male (n =146) 9 1    
  Female (n =74) 4     
BMI <22 (n =109) 3 0.083    NS
  >25 (n =33) 1 0.697    
Diabetes mellitus Positive (n =39) 2 1    
ICGR15 (%); median: 10 >10 (n =129) 8 1    
>15 (n =38) 3 0.475    
Preoperative biliary drainage ENBD (n =110) 4 0.262    
PTBD (n =64) 6     
None (n =46) 3     
Preoperative portal vein embolism Yes (n = 114) 5 0.396    
Preoperative PT-INR; median: 1.1 >1.1 (n =75) 4 1    
Preoperative albumin (mg/dL) <3.9 (n = 112) 7 1    
Type of hepatectomy Left lobectomy (n =79) 6 0.389    
  Right lobectomy/trisegmentectomy (n =139) 7     
  Other (n =2) 0     
PD Yes (n =30) 0 0.224    
Operative blood loss (mL) >1700 (n =108) 7 0.781    
  >3000 (n =34) 3 0.429    
  >5000 (n =13) 2 0.174    
Operation time (min) >660 (n =103) 6 1    
Vascular combined resection Hepatic artery (n =24) 2 0.639    
PV (n =118) 7 1    
Number of bile duct reconstructions ≥3 (n =139) 9 0.772    
Postoperative max AST (IU) >440 (n =110) 9 0.251    
Postoperative max ALT (IU) >370 (n =110) 8 0.569    
Platelet count (POD1) <10 x 104/μL (n =30) 5 0.020 3.63 1.15-13.01 0.029
PT-INR (POD1); median: 1.8 >1.8 (n =105) 5 0.769    
APTT (POD1); median: 40 >40 (n =107) 6 1    
Postoperative liver failure Yes (n =28) 3 0.198    
  1. BMI: body mass index, DM: diabetes mellitus, ENBD: endoscopic nasobiliary drainage, PTBD: percutaneous transhepatic biliary drainage, PT-INR: prothrombin time-international normalized ratio, PV: portal vein, ICGR: indocyanine green retention rate at 15 min, PD: pancreaticoduodenectomy, AST: aspartate amino transferase, ALT: alanine aminotransferase, POD: postoperative day, N.S: no statistically significant difference.
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