Table 3 Possible risk factors for anastomotic insufficiency following intrahepatic cholangiojejunostomy
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
Subject characteristics | Anastomotic insufficiency (n =13) | P | Odds ratio | 95% CI | P | |
Age (years) | 68 > (n =102) | 7 | 1 | |||
Sex | Male (n =146) | 9 | 1 | |||
Female (n =74) | 4 | |||||
BMI | <22 (n =109) | 3 | 0.083 | NS | ||
>25 (n =33) | 1 | 0.697 | ||||
Diabetes mellitus | Positive (n =39) | 2 | 1 | |||
ICGR15 (%); median: 10 | >10 (n =129) | 8 | 1 | |||
>15 (n =38) | 3 | 0.475 | ||||
Preoperative biliary drainage | ENBD (n =110) | 4 | 0.262 | |||
PTBD (n =64) | 6 | |||||
None (n =46) | 3 | |||||
Preoperative portal vein embolism | Yes (n = 114) | 5 | 0.396 | |||
Preoperative PT-INR; median: 1.1 | >1.1 (n =75) | 4 | 1 | |||
Preoperative albumin (mg/dL) | <3.9 (n = 112) | 7 | 1 | |||
Type of hepatectomy | Left lobectomy (n =79) | 6 | 0.389 | |||
Right lobectomy/trisegmentectomy (n =139) | 7 | |||||
Other (n =2) | 0 | |||||
PD | Yes (n =30) | 0 | 0.224 | |||
Operative blood loss (mL) | >1700 (n =108) | 7 | 0.781 | |||
>3000 (n =34) | 3 | 0.429 | ||||
>5000 (n =13) | 2 | 0.174 | ||||
Operation time (min) | >660 (n =103) | 6 | 1 | |||
Vascular combined resection | Hepatic artery (n =24) | 2 | 0.639 | |||
PV (n =118) | 7 | 1 | ||||
Number of bile duct reconstructions | ≥3 (n =139) | 9 | 0.772 | |||
Postoperative max AST (IU) | >440 (n =110) | 9 | 0.251 | |||
Postoperative max ALT (IU) | >370 (n =110) | 8 | 0.569 | |||
Platelet count (POD1) | <10 x 104/μL (n =30) | 5 | 0.020 | 3.63 | 1.15-13.01 | 0.029 |
PT-INR (POD1); median: 1.8 | >1.8 (n =105) | 5 | 0.769 | |||
APTT (POD1); median: 40 | >40 (n =107) | 6 | 1 | |||
Postoperative liver failure | Yes (n =28) | 3 | 0.198 | |||