Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study

Table 4 Proportion of patients (%) with important biochemical variables below or above reference value prior to, and at 12 and 24 months after laparoscopic sleeve gastrectomy

Variable	Preoperative	12 months	24 months	P value
				12 vs. 0 months	24 vs. 0 months	24 vs. 12 months
No. with available data/total no:	95-117/117	98-107/117	65-95/117
	No. below or above reference/no with available data (%)
Hb<ref. (11,5-16,0 g/dl)	7/117 (6%)	5/105 (4.8%)	4/95 (4.2%)	1	1	1
Ferritin<ref. (25-300 ug/l)	13/116 (11.2%)	20/101 (19.8%)	28/85 (32.9%)	0.021	0.001	0.118
Folic acid<ref. (> 5 nmol/l)	8/106 (7.5%)	8/100 (8.0%)	2/91 (2.2%)	1	0.453	0.125
Cobalamin<ref. (145–540 pmol/l)	4/111 (3.6%)	7/107 (6.5%)	3/94 (3.2%)	0.508	1	0.727
25(OH)D<ref. (30-150 nmol/l)	29/110 (26.4%)	5/105 (4.8%)	8/79 (10.1%)	<0.001	<0.001	0.289
25(OH)D<50 nmol/l)	73/110 (66.4%)	39/105 (37.1%)	24/79 (30.4%)	<0.001	<0.001	0.839
1,25(OH)₂D>ref. (50-145 pmol/l)	0/104 (0.0%)	3/98 (3.1%)	1/65 (1.5%)	0.250	1	1
ALP>ref. (< 105 U/l)	6/116 (5.2%)	5/107 (4.7%)	7/94 (7.4%)	1	1	0.688
PTH>ref. (1.6-7.0 pmol/l)	35/95 (36.8%)	42/105 (40.0%)	36/85 (42.4%)	0.719	0.571	0.664
Calcium<ref. (2.15 – 2.55 mmol/l)	6/117 (5.1%)	1/108 (0.9%)	1/93 (1.1%)	0.124	0.125	1
Albumin<ref. (35-50 g/l)	16/117 (13.7%)	4/107 (3.7%)	8/94 (8.5%)	0.008	0.180	0.453
ALT>ref (35 U/l)	50/117 (42.7%)	11/107 (10.3%)	11/93 (11.8%)	<0.001	<0.001	1

No = Number. Hb = Hemoglobin. Ref = Reference value. 25(OH)D = 25 hydroxyvitamin D. 1,25(OH)₂D = 1,25 dihydroxyvitamin D. ALP = Alkaline Phosphatase. PTH = Parathyroid hormone. ALT = Alanine aminotransferase.

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