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Table 4 Proportion of patients (%) with important biochemical variables below or above reference value prior to, and at 12 and 24 months after laparoscopic sleeve gastrectomy

From: Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study

Variable Preoperative 12 months 24 months P value
     12 vs. 0 months 24 vs. 0 months 24 vs. 12 months
No. with available data/total no: 95-117/117 98-107/117 65-95/117    
  No. below or above reference/no with available data (%)    
Hb<ref. (11,5-16,0 g/dl) 7/117 (6%) 5/105 (4.8%) 4/95 (4.2%) 1 1 1
Ferritin<ref. (25-300 ug/l) 13/116 (11.2%) 20/101 (19.8%) 28/85 (32.9%) 0.021 0.001 0.118
Folic acid<ref. (> 5 nmol/l) 8/106 (7.5%) 8/100 (8.0%) 2/91 (2.2%) 1 0.453 0.125
Cobalamin<ref. (145–540 pmol/l) 4/111 (3.6%) 7/107 (6.5%) 3/94 (3.2%) 0.508 1 0.727
25(OH)D<ref. (30-150 nmol/l) 29/110 (26.4%) 5/105 (4.8%) 8/79 (10.1%) <0.001 <0.001 0.289
25(OH)D<50 nmol/l) 73/110 (66.4%) 39/105 (37.1%) 24/79 (30.4%) <0.001 <0.001 0.839
1,25(OH)2D>ref. (50-145 pmol/l) 0/104 (0.0%) 3/98 (3.1%) 1/65 (1.5%) 0.250 1 1
ALP>ref. (< 105 U/l) 6/116 (5.2%) 5/107 (4.7%) 7/94 (7.4%) 1 1 0.688
PTH>ref. (1.6-7.0 pmol/l) 35/95 (36.8%) 42/105 (40.0%) 36/85 (42.4%) 0.719 0.571 0.664
Calcium<ref. (2.15 – 2.55 mmol/l) 6/117 (5.1%) 1/108 (0.9%) 1/93 (1.1%) 0.124 0.125 1
Albumin<ref. (35-50 g/l) 16/117 (13.7%) 4/107 (3.7%) 8/94 (8.5%) 0.008 0.180 0.453
ALT>ref (35 U/l) 50/117 (42.7%) 11/107 (10.3%) 11/93 (11.8%) <0.001 <0.001 1
  1. No = Number. Hb = Hemoglobin. Ref = Reference value. 25(OH)D = 25 hydroxyvitamin D. 1,25(OH)2D = 1,25 dihydroxyvitamin D. ALP = Alkaline Phosphatase. PTH = Parathyroid hormone. ALT = Alanine aminotransferase.