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Table 2 CMV-Prophylaxis

From: Effect of delayed CNI-based immunosuppression with Advagraf® on liver function after MELD-based liver transplantation [IMUTECT]

CMV- positive donor

Valganciclovir for 3 months:

- 2 × 450 mg/d per os during the 1st and 2nd week after LT

- 1 × 450 mg/d per os thereafter

- Reduced dosages in case of renal dysfunction creatinine clearance (ml/min):

- 40-59: 1 × 450 mg/d

- 25-39: 450 mg every 2nd day

- 10-24: 450 mg 2x/week

 

- Patients under dialysis: 450 mg 2x/week

 

Ganciclovir i.v.:

- 2x/d 5 mg/kg

- Reduced dosages in case of renal dysfunction creatinine clearance (ml/min):

- 49-10: 1x/d 2,5 mg/kg

- <10: 1,25 mg/kg 2x/week

 

- Patients under dialysis: 1x/d 1,25 mg/kg