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Table 8 Other surgery types

From: Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review

Surgery type

Author and year

Comparator and patients per arm (n)

Primary endpoint

Principal results

Gynaecologic surgery

Angioli 2009[23]

Floseal® (8)

Control of minor bleeding

Not significant differences in the time to haemostasis, blood loss, or the operating time.

Control (bipolar forceps or carbon-dioxide laser) (12)

Raga 2009[24]

Floseal® (25)

Haemostatic efficacy

Less intra- and postoperative blood loss (p = 0.001) and a lower rate of transfusions (0% in the Floseal® group) (p < 0.001) for patients treated with Floseal®. A shorter length of hospital stay in the Floseal® group (p = 0.005).

Isotonic sodium chloride (25)

Sönmezer 2013[25]

Floseal® (13)

Ovarian reserve and damage

During the first postoperative month, ovarian damage was significantly lower in the Floseal® group (p < 0.001). However, at the third month after surgery, NS differences were found.

Bipolar electrosurgical coagulation (15)

Lacrimal surgery

Durrani 2007

Floseal® (10)

Postoperative bleeding and patient comfort

Nine patients in the Floseal® group had no or minimal bleeding; this finding was statistically significant at all three measured time points (immediately (p = 0.047), at 12 h (p = 0.006), and at 24 h after surgery (p = 0.005)). The Floseal® group also had less postoperative discomfort (p = 0.0001). 

Without Floseal® (10)

Thyroid surgery

Testini 2009[22]

Floseal® (54)

Operating time and wound drain removal

A significantly shorter operating time in the Floseal® group than in the other groups (p < 0.05). More rapid wound drain removal and a shorter length of hospital stay in the Floseal® group compared with the other groups (p < 0.05 both). Not significant difference in postoperative morbidity.

Surgical haemostasis (49)

Tabotamp (52)