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Table 5 Orthopaedic surgery

From: Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review

Author and year Comparator and patients per arm (n) Primary endpoint Principal results
Comadoll 2012[11] Floseal® (184) Pre- and postoperative decreases in haemoglobin decreases Floseal® resulted in less reduction in haemoglobin than did the use of conventional haemostatic methods (p < 0.0001).
Conventional haemostatic methods (Electrocautery, suturing, or manual compression) (165)
Kim 2012[9] Floseal® (97) Blood loss measured through drain output Floseal® had no demonstrable effect on blood loss, as measured through drain output.
Electrocautery (99)
Velyvis 2012[10] Floseal® (83) Blood loss measured through drain output Floseal® significantly reduced blood loss (p = 0.0001) and blood transfusion requirements (p = 0.07).
Conventional method (100)