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Table 3 Overview of the studies identified

From: Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review

Surgery type Author and year Country Study type (N) Therapy
Cardiac surgery Krishnan 2009[6] US Retrospective chart study review (36,950) Haemostatic agent
Nasso 2009[7] Italy Prospective randomised controlled trial (415) Haemostatic agent
Sugarman 2013[8] US Economic evaluation Haemostatic agent
Gyneacologic surgery Angioli 2009[23] Italy Prospective randomised controlled trial (20) Conventional method
Raga 2009[24] Spain Prospective randomised controlled trial (50) Conventional method
Sönmezer 2013[25] Germany Prospective randomised controlled trial (30) Conventional method
Lacrimal surgery Durrani 2007[32] UK Cases and controls (20) Conventional method
Orthopaedic surgery Comadoll 2012[11] US Retrospective chart study review (349) Conventional method
Kim 2012[9] US Prospective randomised controlled trial (195) Conventional method
Velyvis 2012[10] US Cases and controls (183) Conventional method
Sinus Surgery Baumann 2003[19] Switzerland Cases and controls (100) Haemostatic agent
Beyea 2011[21] Canada Prospective randomised controlled trial (20) Haemostatic agent
Chandra 2003[16] US Prospective randomised controlled trial (20) Haemostatic agent
Chandra 2005[17] US Prospective randomised controlled trial (18) Haemostatic agent
Jameson 2006[20] US Prospective randomised controlled trial (45) Conventional method
Shrime 2007[18] US Retrospective chart study review (172) Conventional method
Thyroid surgery Testini 2009[22] Italy Prospective randomised controlled trial (155) Haemostatic agent
Tonsillectomy/adenoidectomy Blackmore 2008[12] UK Prospective randomised controlled trial (30) Conventional method
Jo 2007[15] US Prospective randomised controlled trial (68) Conventional method
Mathiasen 2004[14] US Prospective randomised controlled trial (70) Conventional method
Mozet 2012[13] Germany Prospective randomised controlled trial (176) Conventional method
Urologic procedures Gill 2005[26] US Cases and controls (131) Conventional method
Guzzo 2009[28] US Cases and controls (40) Haemostatic agent
Koni 2012[27] Turkey Prospective randomised controlled trial (43) Haemostatic agent
Nogueira 2008[29] US Cases and controls (35) Haemostatic agent
Pace 2010[30] Italy Prospective randomised controlled trial (30) Conventional method
Waldert 2011[31] Austria Cases and controls (142) Conventional method
  1. US: United States.