Figure 8
Effect of caveolar impairment on injury-induced signalling in the luminal face of rat aorta. Pre-treatment with 10 mM MβCD to disrupt caveolae does not significantly affect the Ca2+ response to endothelial damage (A), but fully abolishes the accompanying NOP (C). B, MβCD effect on both the peak and the plateau of the Ca2+ elevation. The traces are the mean±SE, respectively, of 5 (PSS, closed circles) and 4 (MβCD, open circles) cells from two aortic rings harvested from the same animal on the same day. D, MβCD effect on NOP amplitude measured at 20 min after the injury. For both B and D, the number of ECs analyzed in each condition is indicated above the bars.