Figure 6

Connexin mimetic peptides do not impair injury-induced elevation in [Ca²⁺] _i in rat aortic endothelium. A, 1 hour pre-incubation with either ^37,43Gap27 (300 μM) (gray trace) or ⁴⁰Gap27 (300 μM) (dark grey trace) did not reduce injury-elicited intracellular Ca²⁺ signals in native endothelium of rat aorta. B, 2 hour pre-incubation with both ^37,43Gap27 (300 μM) and ⁴⁰Gap27 (300 μM) (grey trace) did not impair the intracellular Ca²⁺ response to injury at wound edge of rat aortic endothelium. C and D, mean±SE of NOP elicited by injury following the designated treatments. The asterisk indicates a level of significant difference <0.05. The number of ECs analyzed in each condition is indicated above the bars.