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Table 1 Timing of study procedures

From: Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial

Parameters

  

Timepoints

SEH

Surgical procedure

Postoperative days

 

Anesthesia

30 minutes after intervention

Pre-anhepatic phase

Anhepatic phase

Reperfusion phase

0/1

2

3

4

5

6

7

11

14

30

12-leads ECG

x

According to local protocol

  

x

   

x

   

Lab

x

x

x

x

x

x

x

x

 

x

x

Troponin

x

x

         

Plasma sample

x

x

x

1 hour after intervention

15 minutes after start phase

15 minutes after start phase

x

 

x

 

x

  

x

  

2 hours after intervention

end of surgery

Viral safety

x

               

TEG/ROTEM

    

15 minutes after start phase

30 minutes after start phase

          

Blinded INR

  

x

   

x

 

x

   

x

   

Ultrasound hepatic vessels

 

According to local protocol

    

first 24 h after surgery

     

Registration transfusion products

  

x

x

x

x

  

x

   

x

   

Physical examination with focus on thrombotic and ischemic events

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