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Table 2 Definitions of isolated tumor cells (ITCs) and micrometastases (MMS)

From: The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute Study

Definitions used in EnRoute Study
  Isolated Tumor Cells (ITCs) Micrometastases (MMs)
Size < 0.2 mm 0.2 - 2 mm
Localization No defining criterion No defining criterion
Detection method HES and/or IHC HES and/or IHC
Formal designation (present vs absent) pN0i+ vs pN0i- pN0mi+ vs pN0mi-
Designation for study purposes if present pN0micro+ pN0micro+
  1. HES hematoxylin and eosin stain; IHC immunohistochemistry.