Table 5 Univariate and multivariate analyses of clinicopathological factors for OS in stage III GC
Variables | β | Univariate | P-Value | β | Multivariate | P-Value | ||
|---|---|---|---|---|---|---|---|---|
Wald | HR(95%CI) | Wald | HR(95%CI) | |||||
Preoperative CEA(ng/mL) | ||||||||
≤ 5 | ||||||||
> 5 | 0.175 | 0.517 | 1.191(0.739–1.920) | 0.472 | ||||
Preoperative CA19-9(U/mL) | ||||||||
≤ 35 | ||||||||
> 35 | 0.897 | 13.65 | 2.451(1.523–3.945) | < 0.001 | 0.63 | 5.726 | 1.878(1.121–3.147) | 0.017 |
Preoperative CA72-4(U/mL) | ||||||||
≤ 6.9 | ||||||||
> 6.9 | 0.169 | 0.387 | 1.184(0.696–2.014) | 0.534 | ||||
Age(years) | ||||||||
≤ 60 | ||||||||
> 60 | 0.509 | 2.592 | 1.663(0.895–3.088) | 0.107 | ||||
Gender | ||||||||
Female | ||||||||
Male | -0.234 | 0.845 | 0.791(0.481–1.303) | 0.358 | ||||
Tumor location | 1.962 | 0.58 | ||||||
Upper | ||||||||
Middle | -0.268 | 0.651 | 0.765(0.399–1.467) | 0.42 | ||||
Lower | -0.374 | 1.871 | 0.688(0.402–1.176) | 0.171 | ||||
Other | -0.099 | 0.033 | 0.906(0.312–2.629) | 0.855 | ||||
Tumor size(cm) | ||||||||
<5 | ||||||||
≥ 5 | 0.593 | 6.167 | 1.810(1.133–2.890) | 0.013 | 0.324 | 1.69 | 1.382(0.848–2.252) | 0.194 |
Vascular invasion | ||||||||
No | ||||||||
Yes | 0.175 | 0.328 | 1.191(0.654–2.169) | 0.567 | ||||
Nerve invasion | ||||||||
No | ||||||||
Yes | 0.785 | 3.908 | 2.193(1.007–4.779) | 0.048 | 0.756 | 3.558 | 2.129(0.971–4.669) | 0.059 |
Degree of differentiation | ||||||||
Moderately | ||||||||
Poorly | 0.42 | 0.822 | 1.522(0.614–3.773) | 0.365 | ||||
Depth of invasion | ||||||||
T2-T3 | ||||||||
T4 | 0.171 | 0.506 | 1.186(0.741-1.900) | 0.477 | ||||
Lymph node metastasis | ||||||||
N0-N1 | ||||||||
N2-N3 | 0.726 | 3.73 | 2.067(0.989–4.318) | 0.053 | ||||
Postoperative adjuvant chemotherapy(PAC) | ||||||||
No | ||||||||
Yes | -0.515 | 4.661 | 0.598(0.374–0.954) | 0.031 | -0.597 | 6.043 | 0.550(0.342–0.886) | 0.014 |
Postoperative CEA(ng/mL) | ||||||||
≤ 5 | ||||||||
> 5 | 0.267 | 1.181 | 1.307(0.807–2.117) | 0.277 | ||||
Postoperative CA19-9(U/mL) | ||||||||
≤ 35 | ||||||||
> 35 | 1.104 | 18.366 | 3.015(1.820–4.995) | < 0.001 | 0.632 | 5.006 | 1.881(1.081–3.270) | 0.025 |
Postoperative CA72-4(U/mL) | ||||||||
≤ 6.9 | ||||||||
> 6.9 | 0.828 | 9.295 | 2.288(1.344–3.897) | 0.002 | 0.555 | 3.611 | 1.741(0.983–3.085) | 0.057 |