Table 4 Univariate and multivariate analyses of clinicopathological factors for RFS in stage III GC
Variables | β | Univariate | P-Value | β | Multivariate | P-Value | ||
|---|---|---|---|---|---|---|---|---|
Wald | HR(95%CI) | Wald | HR(95%CI) | |||||
Preoperative CEA(ng/mL) | ||||||||
≤ 5 | ||||||||
> 5 | 0.528 | 5.738 | 1.696(1.101–2.614) | 0.017 | 0.37 | 2.473 | 1.448(0.913–2.296) | 0.116 |
Preoperative CA19-9(U/mL) | ||||||||
≤ 35 | ||||||||
> 35 | 1.049 | 21.688 | 2.853(1.835–4.436) | < 0.001 | 0.619 | 6.154 | 1.858(1.139–3.031) | 0.013 |
Preoperative CA72-4(U/mL) | ||||||||
≤ 6.9 | ||||||||
> 6.9 | 0.232 | 0.848 | 1.261(0.770–2.064) | 0.848 | ||||
Age(years) | ||||||||
≤ 60 | ||||||||
> 60 | 0.241 | 0.823 | 1.273(0.756–2.145) | 0.364 | ||||
Gender | ||||||||
Female | ||||||||
Male | 0.274 | 1.067 | 1.316(0.782–2.214) | 0.302 | ||||
Tumor location | 2.344 | 0.504 | ||||||
Upper | ||||||||
Middle | 0.275 | 0.796 | 1.317(0.719–2.413) | 0.372 | ||||
Lower | 0.011 | 0.002 | 1.011(0.597–1.711) | 0.967 | ||||
Other | -0.716 | 0.934 | 0.489(0.114–2.088) | 0.334 | ||||
Tumor size(cm) | ||||||||
<5 | ||||||||
≥ 5 | 0.376 | 2.955 | 1.456(0.949–2.236) | 0.086 | ||||
Vascular invasion | ||||||||
No | ||||||||
Yes | 0.401 | 1.766 | 1.493(0.827–2.695) | 0.184 | ||||
Nerve invasion | ||||||||
No | ||||||||
Yes | 0.191 | 0.428 | 1.211(0.682–2.148) | 0.513 | ||||
Degree of differentiation | ||||||||
Moderately | ||||||||
Poorly | 0.866 | 2.854 | 2.377(0.871–6.488) | 0.091 | ||||
Depth of invasion | ||||||||
T2-T3 | ||||||||
T4 | 0.076 | 0.111 | 1.078(0.691–1.683) | 0.74 | ||||
Lymph node metastasis | ||||||||
N0-N1 | ||||||||
N2-N3 | 1.009 | 6.523 | 2.743(1.265–5.951) | 0.011 | 0.917 | 5.205 | 2.502(1.138–5.503) | 0.023 |
Postoperative adjuvant chemotherapy(PAC) | ||||||||
No | ||||||||
Yes | 0.123 | 0.322 | 1.131(0.739–1.732) | 0.571 | ||||
Postoperative CEA(ng/mL) | ||||||||
≤ 5 | ||||||||
> 5 | 0.791 | 12.946 | 2.205(1.433–3.392) | < 0.001 | 0.029 | 0.011 | 1.030(0.593–1.787) | 0.917 |
Postoperative CA19-9(U/mL) | ||||||||
≤ 35 | ||||||||
> 35 | 1.475 | 40.016 | 4.370(2.767–6.901) | < 0.001 | 0.902 | 9.598 | 2.464(1.393–4.359) | 0.002 |
Postoperative CA72-4(U/mL) | ||||||||
≤ 6.9 | ||||||||
> 6.9 | 1.252 | 26.774 | 3.497(2.2176–5.619) | < 0.001 | 0.938 | 11.146 | 2.555(1.473–4.432) | 0.001 |