Table 3 Univariable and multivariable cox regression models predicting CSS and OS of 265 patients with UTUC after radical nephroureterectomy

Age, continuous

1.01 (0.99–1.03)

0.282

0.99 (0.97–1.02)

0.641

1.03 (1.01–1.04)

0.011

1.02 (0.99–1.04)

0.159

 Male

1

0.681

1

0.93

1

0.827

1

0.66

 Female

1.11 (0.68–1.80)

1.03 (0.56–1.88)

1.05 (0.67–1.64)

0.89 (0.53–1.50)

 No

1

0.171

1

0.302

1

0.113

1

0.119

 Yes

1.37 (0.87–2.14)

1.34 (0.77–2.36)

1.38 (0.93–2.04)

1.46 (0.91–2.34)

 No

1

0.115

1

0.439

1

0.058

1

0.149

 Yes

1.47 (0.91–2.38)

1.30 (0.67–2.50)

1.51 (0.99–2.32)

1.51(0.86–2.65)

 No

1

0.606

1

0.833

1

0.926

1

0.966

 Yes

1.24 (0.54–2.86)

1.23 (0.37–3.48)

0.96 (0.42–2.19)

1.02 (0.39–2.69)

 No

1

0.636

1

0.712

1

0.48

1

0.411

 Yes

1.14 (0.66–1.97)

1.13 (0.60–2.14)

0.83 (0.49–1.41)

0.77 (0.42–1.43)

 Left

1

0.512

1

0.11

1

0.772

1

0.23

 Right

0.87 (0.56–1.33)

1.50 (0.91–2.45)

0.95 (0.65–1.38)

1.30 (0.85–1.99)

 Renal pelvis

1

0.029

0.07

1

0.4

1

0.458

 Ureter

1.35 (0.85–2.15)

1.77 (0.93–3.37)

1.15 (0.77–1.72)

1.31 (0.76–2.25)

 Renal pelvis and ureter

2.61 (1.28–5.34)

2.69 (1.08–6.70)

1.62 (0.79–3.32)

1.63 (0.70–3.78)

Tumor size, continuous

1.13 (1.03–1.26)

0.015

1.07 (0.95–1.21)

0.268

1.09 (0.99–1.19)

0.083

1.05 (0.94–1.18)

0.364

 Unifocal

1

0.07

1

0.871

1

0.085

1

0.694

 Multifocal

1.49 (0.97–2.28)

0.96 (0.58–1.60)

1.40 (0.96–2.04)

1.09 (0.70–1.70)

LVI

 No

1

< 0.001

1

0.003

1

< 0.001

1

0.002

 Yes

2.20 (1.54–3.13)

2.0 (1.26–3.17)

2.20 (1.50–3.23)

1.88 (1.25–2.83)

 Low

1

< 0.001

< 0.001

1

< 0.001

1

0.001

 High

11.23 (4.89–25.81)

6.95 (2.87–16.83)

4.03 (2.47–6.56)

2.59 (1.50–4.49)

 pT1

1

< 0.001

0.002

1

< 0.001

1

0.004

 pT2

1.91 (0.75–4.84)

1.69 (1.11–2.59)

1.36 (0.69–2.70)

1.40 (0.91–2.14)

 pT3/pT4

7.40 (3.55–15.43)

2.83 (1.20–6.66)

4.12 (2.43–6.99)

2.29 (1.21–4.36)

 pN0

1

0.429

1

0.494

1

0.785

1

0.645

 pNx

0.84 (0.55–1.29)

0.84 (0.51–1.38)

0.95 (0.64–1.40)

0.90 (0.59–1.39)

 Extravesical

1

0.434

1

0.277

1

0.538

1

0.921

 Open intravesical

1.09 (0.65–1.85)

1.35 (0.75–2.41)

0.77 (0.49–1.22)

0.93 (0.57–1.52)

 Endoscopic

0.73 (0.36–1.48)

0.74 (0.30–1.84)

0.87 (0.50–1.50)

0.86 (0.41–1.82)

 No

1

< 0.001

1

0.111

1

< 0.001

1

0.331

 Yes

2.93 (1.88–4.56)

1.54 (0.90–2.63)

2.13 (1.40–3.22)

1.28 (0.78–2.09)

 ONU

1

0.191

1

0.444

1

0.909

1

0.17

 LNU

0.67 (0.37–1.22)

1.38 (0.61–3.13)

1.03 (0.65–1.63)

1.61 (0.82–3.17)