Table 2 Univariable and multivariable cox regression models predicting intravesical RFS and Overall RFS of 265 patients with UTUC after radical nephroureterectomy

Age, continuous

0.99 (0.96–1.01)

0.359

0.98 (0.96–1.01)

0.239

1.00 (0.99–1.01)

0.981

0.99 (0.97–1.01)

0.232

 Male

1

0.181

1

0.07

1

0.94

1

0.258

 Female

0.59 (0.28–1.3)

0.45 (0.19–1.07)

1.02 (0.69–1.50)

0.77 (0.48–1.22)

 No

1

0.273

1

0.357

1

0.021

1

0.057

 Yes

1.41 (0.76–2.58)

1.41 (0.68–2.89)

1.54 (0.07–2.22)

1.52 (0.99–2.33)

 No

1

0.768

1

0.269

1

0.08

1

0.83

 Yes

1.10 (0.59–2.03)

0.65 (0.30–1.40)

1.41 (0.96–2.08)

0.94 (0.56–1.59)

 No

1

0.394

1

0.491

1

0.8

1

0.291

 Yes

1.56 (0.56–4.7)

0.65 (0.19–2.24)

1.10 (0.52–2.37)

1.60 (0.67–3.84)

 No

1

0.048

1

0.014

1

0.369

1

0.585

 Yes

1.95 (1.01–3.76)

2.71 (1.22–5.99)

1.23 (1.79–1.91)

1.15 (0.70–1.89)

 Left

1

0.276

1

0.573

1

0.789

1

0.534

 Right

1.38 (0.77–2.48)

1.20 (0.64–2.24)

0.95 (0.68–1.35)

1.13 (0.78–1.64)

 Renal pelvis

1

0.093

1

0.129

1

0.001

1

0.003

 Ureter

1.67 (0.89–3.17)

1.57 (0.65–3.78)

1.25 (0.86–1.80)

1.60 (0.96–2.67)

 Renal pelvis and ureter

2.82 (1.02–7.78)

3.72 (1.04–13.25)

3.15 (1.74–5.71)

3.52 (1.70–7.26)

Tumor size, continuous

0.90 (0.76–1.06)

0.209

0.91 (0.74–1.11)

0.353

1.07 (0.98–1.17)

0.112

1.02 (0.92–1.13)

0.682

 Unifocal

1

0.608

1

0.757

1

0.015

1

0.492

 Multifocal

1.17 (0.65–2.09)

1.12 (0.56–2.23)

1.54 (1.09–2.17)

1.15 (0.77–1.72)

 No

1

0.582

1

0.746

1

< 0.001

1

< 0.001

 Yes

0.83 (0.42–1.63)

0.89 (0.43–1.83)

2.20 (1.54–3.13)

2.03 (1.39–2.96)

 Low

1

0.91

1

0.525

1

< 0.001

1

< 0.001

 High

0.97 (0.54–1.74)

0.79 (0.39–1.62)

3.72 (2.41–5.73)

2.47 (1.51–4.03)

 pT1

1

0.434

1

0.471

1

< 0.001

1

< 0.001

 pT2

1.48 (0.70–3.10)

1.18 (0.52–2.67)

1.54 (0.86–2.76)

1.72 (1.06–3.03)

 pT3/pT4

0.96 (0.48–1.93)

1.67 (0.73–3.78)

3.46 (2.18–5.50)

2.57 (1.47–4.48)

 pN0

1

0.097

1

0.308

1

0.489

1

0.677

 pNx

1.73 (0.91–3.28)

1.45 (0.71–2.94)

1.13 (0.79–1.62)

1.09 (0.74–1.61)

 Extravesical

1

< 0.001

1

< 0.001

1

0.011

1

0.129

 Open intravesical

0.32 (0.18–0.59)

0.25 (0.13–0.50)

0.63 (0.43–0.94)

0.73 (0.47–1.12)

 Endoscopic

0.17 (0.06–0.49)

0.11 (0.03–0.42)

0.46 (0.27–0.79)

0.52 (0.27–1.01)

 No

1

0.043

1

0.033

1

0.035

1

0.194

 Yes

0.35 (0.12–0.97)

0.28 (0.09–0.90)

1.52 (1.03–2.26)

0.74 (0.46–1.17)

 ONU

1

0.211

1

0.622

1

0.082

1

0.974

 LNU

0.58 (0.25–1.34)

1.23 (0.46–3.65)

0.66 (0.41–1.06)

0.99 (0.54–1.83)