Organ Failure | Circulatory | Systolic blood pressure less than 90 mm hg or need for catecholamine support | |
---|---|---|---|
 | Pulmonary | PaO2 60 mm Hg or less or need for mechanical ventilation | |
 | Renal | creatinine level greater than 177 umol/L after rehydration or or need for hemofiltration or hemodialysis | |
Systemic complications | Gastrointestinal bleeding | more than 500 ml/24 hours | |
 | Disseminated intravascular coagulation | platelets <100 × 109/L | |
 | Severe metabolic disturbance | calcium level <1.87 mmol/L |