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The C-seal trial: colorectal anastomosis protected by a biodegradable drain fixed to the anastomosis by a circular stapler, a multi-center randomized controlled trial

  • Ilsalien S Bakker1Email author,
  • Annelien N Morks2,
  • Henk O ten Cate Hoedemaker1,
  • Johannes G M Burgerhof3,
  • Henri G Leuvenink1,
  • Rutger J Ploeg4 and
  • Klaas Havenga1
BMC Surgery201212:23

DOI: 10.1186/1471-2482-12-23

Received: 9 October 2012

Accepted: 12 November 2012

Published: 15 November 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
9 Oct 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
11 Oct 2012 Author responded Author comments - Ilsalien Bakker
Resubmission - Version 3
11 Oct 2012 Submitted Manuscript version 3
25 Oct 2012 Reviewed Reviewer Report - Hubert Scheidbach
Resubmission - Version 4
Submitted Manuscript version 4
12 Nov 2012 Editorially accepted
15 Nov 2012 Article published 10.1186/1471-2482-12-23

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Surgery, University Medical Center Groningen
Department of Surgery, Medical Center Leeuwarden
Department of Epidemiology, University Medical Center Groningen
Nuffield Department of Surgical Sciences, University of Oxford